نوع المستند : المقالة الأصلية
المؤلفون
1
Teaching Assistant, Department of Pharmacology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
2
Professor of pharmacology, Department of Pharmacology, Faculty of Medicine, AinShams University, Cairo, Egypt
3
Lecturer of pharmacology The National Center for Social and Criminological Research, Cairo, Egypt.
4
Lecturer of Clinical Pharmacology, Department of Clinical Pharmacology Faculty of Medicine, Ain Shams University, Cairo, Egypt.
5
Assistant professor of pharmacology, Department of Pharmacology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
المستخلص
Schizophrenia is a common clinical disorder of psychopathology. Olanzapine has proven efficacy to treat positive symptoms of schizophrenia with enhanced tolerability compared to older first generation antipsychotics. The present study was undertaken to explore the possible effects of olanzapine (6 mg/kg/day) on sociality and cognition in isolated reared rats as a model of schizophrenia. Results: It could be seen that sociality (SI)is deteriorated significantly in isolated reared rats which is very suggestive of induction of schizophrenia's negative symptoms and significantly improved by chronic administration of olanzapine to the extent of social reared (SR) group. Chronic administration of olanzapine obviously decreased cognition indicated by decreased (SPI), increased latency to reach target quadrant and decreased % of time spent in target quadrant day Conclusion: olanzapine had a beneficial effect on increasing sociality in isolated reared rats, but it deteriorates spatial memory and novel object recognition.
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